The seventh verse of Surah Al-Duha (And He found you astray, so guide you) has long been a subject of discussion and opinion among commentators of both sects. The views put forward in the interpretation of this verse cover a wide range. The present study, with a descriptive-analytical approach and using the method of interpreting the Quran by the Quran, has analyzed the verse within the framework of Imam Khamenei's thought. The findings of the study show that the aforementioned interpretations, while having different levels of accuracy and validity, can be combined with each other and none of them negates the other. Among them, the interpretation of "polytheistic misguidance" is unanimously rejected by scholars of both sects; the view of "human's inherent lack of guidance" is also known as a profound interpretation and in line with Imam Khamenei's approach; And lower interpretations such as “lost in childhood” or “unfamiliarity with trade” are acceptable as historical layers of the meaning of the verse, throughout the higher levels. But what is presented as the deepest and highest semantic layer of the verse from the perspective of Imam Khamenei is the concept of “inner resurrection.” This theory refers to the state of the Prophet before his mission, who, while possessing a pure nature and rich human themes, lacked access to deep knowledge and the direct path of revelation. This existential loss awaiting guidance, led to a great resurrection within the Prophet with the divine mission; a resurrection that awakened all the deposited themes and became the prelude to a fundamental transformation in human society. This interpretation, which is documented by citing verses from Surahs Al-Alaq and An-Najm, is in complete harmony with the principle of infallibility and previous interpretations at lower levels, and presents a comprehensive, profound, and authentic meaning of the verse.